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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUK1
All Species:
33.94
Human Site:
Y119
Identified Species:
62.22
UniProt:
Q16774
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16774
NP_000849.1
197
21726
Y119
A
T
D
L
R
P
I
Y
I
S
V
Q
P
P
S
Chimpanzee
Pan troglodytes
XP_001142469
475
50955
Y185
A
T
D
L
Q
P
I
Y
I
S
V
Q
P
P
S
Rhesus Macaque
Macaca mulatta
XP_001084363
197
21679
Y119
A
T
D
L
R
P
I
Y
I
S
V
Q
P
P
S
Dog
Lupus familis
XP_532411
198
21967
Y119
K
T
D
L
R
P
I
Y
I
F
V
Q
P
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q64520
198
21899
Y119
K
T
D
L
C
P
I
Y
I
F
V
Q
P
P
S
Rat
Rattus norvegicus
NP_001013133
219
24034
Y140
K
T
D
L
H
P
I
Y
I
S
V
Q
P
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001232001
198
22316
Y119
K
T
D
L
N
P
I
Y
I
S
V
Q
P
P
S
Frog
Xenopus laevis
NP_001087146
198
21955
Y119
K
T
R
L
N
P
I
Y
I
S
I
H
P
P
S
Zebra Danio
Brachydanio rerio
NP_001002126
199
21965
Y119
K
T
D
L
N
P
I
Y
V
S
V
Q
A
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648408
233
25880
L150
R
T
D
L
N
P
I
L
I
F
N
N
P
P
S
Honey Bee
Apis mellifera
XP_624407
194
22137
E110
D
I
E
I
Q
G
V
E
Q
V
K
R
S
S
L
Nematode Worm
Caenorhab. elegans
NP_491243
216
24871
Y139
N
S
H
L
D
A
R
Y
I
L
I
R
A
P
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P15454
187
20619
K106
D
I
D
M
Q
G
V
K
S
V
K
A
I
P
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38.1
98.4
88.8
N.A.
87.8
78
N.A.
N.A.
73.2
68.1
71.8
N.A.
47.6
54.3
50
N.A.
Protein Similarity:
100
40.4
98.9
92.9
N.A.
92.9
84.4
N.A.
N.A.
87.3
82.3
84.9
N.A.
60.5
73
63.4
N.A.
P-Site Identity:
100
93.3
100
86.6
N.A.
80
86.6
N.A.
N.A.
86.6
66.6
73.3
N.A.
60
0
33.3
N.A.
P-Site Similarity:
100
100
100
86.6
N.A.
80
86.6
N.A.
N.A.
86.6
73.3
80
N.A.
60
33.3
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
49.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
68.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
0
0
0
0
8
0
0
0
0
0
8
16
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
16
0
77
0
8
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
24
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
16
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
8
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
16
0
8
0
0
77
0
77
0
16
0
8
0
0
% I
% Lys:
47
0
0
0
0
0
0
8
0
0
16
0
0
0
0
% K
% Leu:
0
0
0
85
0
0
0
8
0
8
0
0
0
0
8
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
31
0
0
0
0
0
8
8
0
0
0
% N
% Pro:
0
0
0
0
0
77
0
0
0
0
0
0
70
93
0
% P
% Gln:
0
0
0
0
24
0
0
0
8
0
0
62
0
0
0
% Q
% Arg:
8
0
8
0
24
0
8
0
0
0
0
16
0
0
0
% R
% Ser:
0
8
0
0
0
0
0
0
8
54
0
0
8
8
85
% S
% Thr:
0
77
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
16
0
8
16
62
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
77
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _